化苑講壇第636期
報告題目：Roles of Distinct Chemical Factors in Hydrolysis Catalyzed by Metalloenzymes and their Synthetic Analogues
報告人：Prof. Rajeev Prabhakar
報告時間：2023年5月19日（周五）上午9:00-11:30
報告地點：東三樓321會議室
個人簡介：
Prof. Rajeev Prabhakar 現就職于University of Miami, Department of Chemistry. 1993年和1995年先后于Meerut University獲Physics, Chemistry, Math學士學位和Physics碩士學位，2003年于Stockholm University獲Quantum Chemistry博士學位。2006年在Emory University完成博士后工作，同年起于University of Miami, Department of Chemistry任教授至今。迄今共在一線學術期刊發表論文96篇，受邀參加學術會議73次。2021年至今任期刊Frontiers in Chemistry(IF=5.22)副主編，“Development of Synthetic Analogues of Metalloenzymes”特刊特約編輯。曾于2007年獲西班牙政府頒發的國際獎項，受邀訪問并擔任三所高校與研究所的客座教授；同年獲the Japan Society for the Promotion of Science (JSPS)受邀訪問六所高校和研究所并擔任客座教授。另獲Wiley Young Investigator Award.
報告簡介：
The selective hydrolysis of the extremely stable phosphoester, peptide and ester bonds of molecules by bio-inspired metal-based catalysts is required in a wide range of biological, biotechnological and industrial applications. Despite the impressive advances made in the field, the ultimate goal of designing efficient synthetic analogues of enzymes for these reactions is still elusive. The existing analogues include both peptidic and non-peptidic compounds. However, due to their structural simplicity they are significantly less efficient than natural enzymes. The development of the next generation of analogues will require a deeper understanding and fusion of diverse chemical factors that influence activities of both natural and synthetic catalysts. They include catalyst-substrate complexation, non-covalent interactions and the electronic nature of the metal ion, ligand environment and nucleophile. Based on our studies, their roles will be discussed for several mono- and binuclear metalloenzymes and their synthetic analogues.
