報告題目： Perfluorophenyl Azides: Applications in Surface Functionalization and Materials Chemistry
報 告 人：顏鳴鏑教授(Prof. Mingdi Yan)(美國麻州大學羅威爾分校)
報告時間：2014年6月9日上午 10：00
報告地點：化學樓二樓一號會議室
報告內容和報告者情況簡介：
顏鳴鏑，博士，美國麻州大學羅威爾分校教授，本科就讀于中國科技大學少年班， 1994年獲得美國Oregon大學有機化學博士學位，1995-1998在美國Ikonos公司任職，1998年起在波特蘭州立大學任助理教授（Assist. Prof）, 2004年起任副教授（Assoc. Prof），2008年起任教授，2011年轉到麻州大學羅威爾分校。主要研究方向是包括有機化學、表面化學和納米技術的交叉學科，在世界知名期刊發表論文百余篇。
Abstarct: Research in our laboratory is at the interface of organic chemistry, surface chemistry, and nanotechnology. The central theme has been the development of conjugation chemistry that is general, efficient, can accommodate molecular diversity, maintain ligand bioaffinity, and give stable and bioactive interfaces. Searching for new conjugation chemistry that can work efficiently for molecules and materials that either lack functional groups or are difficult to derivatize led to the technique of photoaffinity labeling (PAL), where a ligand-photoprobe conjugate is used to analyze the receptor structure. The photoprobe, when activated by light, initiates covalent bond formation with the active site of the receptor, the complex of which is then analyzed to determine the receptor structure. One class of photoprobes, perfluorophenyl azide (PFPA), is among the most used PAL agents due to its high coupling efficiency, excellent storage stability, and ease of preparation. When PFPA is activated by light or heat, singlet perfluorophenyl nitrene is generated that subsequently undergoes insertion or addition reactions with neighboring molecules. We have since applied psubstituted PFPAs as heterobifunctional coupling agents in functionalizing surfaces and nanomaterials. We demonstrate that the method is indeed effective and versatile, and is applicable to small molecules, synthetic polymers, biomolecules as well as carbon materials. Recent work in the synthesis of glyconanomaterials and hybrid nanomaterials will be presented.
