報告題目：Glycosciences: From Synthetic Methods to Glycobiology
糖科學：從糖合成到糖生物學
報 告 人：劉學偉 副教授 (Assoc. Prof. Liu Xuewei)
報告時間：2014年4月21日（周一）16：00-17：30
報告地點：化學樓二樓一號會議室
報告人簡歷：
劉學偉，博士，新加坡南洋理工大學副教授，本科就讀于中國農業大學化學系，1996年在中國農業大學獲得碩士學位，2000年獲得南加州大學化學系博士學位，先后在美國P&G、Chugai Pharma 等公司任職，2003至2005年在加州理工學院做博士后研究，2006年1月起在南洋理工大學化學與生物化學系任助理教授（Assist. Prof）, 2012年起任副教授（Assoc. Prof）。主要研究方向包括有機合成化學、糖化學、糖生物學、藥物化學及功能性材料化學，目前獲得研究經費超過2000,000新幣，在世界知名期刊發表論文百余篇，其中包括3篇J. Am. Chem. Soc., 5篇Angew. Chem. Int. Ed., 2篇Adv. Mater., 1篇Chem. Soc, Rev.。多篇文章被ACS Chemical & Engineering News, nature publishing group, Angewandte, Synfacts, ChemistryViews 等highlight和評論。
學術兼職：
2002年-至今 美國紐約科學院成員
2012年-至今 亞洲糖生物學和糖工程通信(ACGG)指導委員會成員
2013年-至今 《中國藥學》英文版 編委
獲獎：
2006 The 1st Asian Core Program (ACP) Lectureship Award (to Japan)
2007 Excellent Presentation Award, Thailand
2009 Young Researcher Award
2011The 6th Asian Core Program (ACP) Lectureship Award (to Korea)
2011The 6th Asian Core Program (ACP) Lectureship Award (to Taiwan)
2012 CoS Collaborative Research Award
The 7th Asian Core Program (ACP) Lectureship Award (to China)
Abstarct:
Ubiquitously decked on the surfaces of all cell types in nature, oligosaccharide molecules play central roles in the development, cooperation and vitality of an organism. Multitudinous approaches to make glycosidic bonds in a highly stereoselective manner have speedingly emerged for the last two decades. Nonetheless, an efficient and universal method to confidently synthesize various glycoconjugates have yet been established, especially one that is applicable for large scale and combinatorial chemistry. There are many reasons for the nascent state of carbohydrate researches, including the advent formation of new stereogenic center after every glycosylation step, the arduous characterization and purification thereafter, as well as the common expression of carbohydrate chains in a nonlinear, branched fashion. Extensive efforts are ongoing in our research group to overcome these challenges. Here, we present direct and reliable synthetic approaches that readily provides oligosaccharides and C-glycosides with not only exclusive anomeric stereoselectivity but also a wide range of derivatizations. Based on our synthetic expertise, we have developed new systems for sensing cellular proteins and events.
