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教育與研究經歷

1986.9.－1989.7.  重慶鋼鐵專科學校化學系學習

1993.9.－1995.7.  華中理工大學化學系攻讀碩士學位

1995.9.－1998.11. 華中理工大學藥物研究所攻讀博士學位

1998.11.－2000.5. 華中理工大學化學系講師

2000.6.－2001.8.  華中科技大學化學系副教授

2001.9－2002.8.   Department of Integrative Biology & Pharmacology, The University of Texas, Medical School at Houston 訪問學者

2002.9.－2004.10. 華中科技大學化學系副教授

2004.11－現在    華中科技大學化學系教授、博士生導師

研究領域與興趣

有氧呼吸過程中產生的活性氧，在病理條件下所致的氧化還原調控失衡，以及病理條件下過量產生的一氧化氮及其代謝過程中形成其他形式的活性氮，是導致衰老、神經退行性疾病、糖尿病和炎癥炎等的重要因素。在活性氧和活性氮的產生及其所致的機體損傷中，微量元素鐵起了重要的介導作用。本課題組基礎研究以活性氧和活性氮的生物化學為中心，涉及過渡金屬離子催化活性氧和活性氮的產生及蛋白質損傷，及其以活性氧和活性氮的抑制為主的天然藥物藥理學評價，

此外，課題組還進行一些應用研究，目前在硅酸鹽濕法分解技術開發方面已經與合作單位獲得兩項專利授權，并正在進行產業化開發。

教學情況

主講化學院本科生《無機化學》《基礎化學實驗》、醫學院五年制臨床專業《基礎化學》。

承擔項目與課題

國家自然科學基金：

蛋白質硝化對糖尿病心血管并發癥病理過程的影響研究(No. 30300073)

鐵過載肝中的蛋白質酪氨酸硝化及黃芩苷的干預作用研究(No. 30670481)

Ab-鐵卟啉復合物催化神經系統蛋白質酪氨酸硝化修飾的反應特性與生理影響(No. 31170808)

學術兼職

中國生物物理學會自由基專業委員會委員

中國活性氧生物學效應專業委員會委員

武漢市微量元素與健康研究會理事長

代表性成果

1. Yi Huang, Youxia Shuai, Hailing Li, Zhonghong Gao^!*. Tyrosine residues play an important role in heme detoxification by serum albumin. Biochimica et Biophysica Acta-General Subjects. 2014, 1840(3):970-6
2. Can Yuan, Zhonghong Gao^!*. Abinteracts with both the iron center and the porphyrin ring of heme: mechanism of heme’s action on Abaggregation and disaggregation. Chemical Research in Toxicology. 2013, 26(2):262-9. 
3. Min Tu, Hayder A. Abbood, Zhening Zhu, Hailing Li, Zhonghong Gao^!*. Investigation of the photocatalytic effect of zinc oxide nanoparticles in the presence of nitrite. Journal of Hazardous Materials. 2013, 244-245: 311-321.
4. Min Tu, Yi Huang, Hailing Li, Zhonghong Gao^!*. The stress caused by nitrite with titanium dioxide nanoparticles under UVA irradiation in human keratinocyte cell. Toxicology. 2012, 299: 60-68.
5. Can Yuan, Lian Yi, Zhen Yang, Qingqing Deng, Yi Huang, Hailing Li, Zhonghong Gao^!*. Amyloid-beta-heme peroxidase promoted protein nitrotyrosination: relevance to widespread protein nitration in Alzheimer’s disease. Journal of Biological Inorganic Chemistry. 2012, 17(2):197-207.
6. Naihao Lu, Yan Zhang, Hailing Li, Zhonghong Gao ^!*. Oxidative and nitrative modifications of alpha-enolase in cardiac proteins from diabetic rats. Free Radical Biology & Medicine. 2010 48(7):873-881
7. Yan Zhang, Naihao Lu, Zhonghong Gao^!*. Hemin-H2O2-NO2- induced protein oxidation and tyrosine nitration is different from that of SIN-1: A study on glutamate dehydrogenase nitrative/oxidative modification. International Journal of Biochemistry and Cell Biology. 2009, 41(4):907-15.
8. Naihao Lu, Zhening Zhu, Xuqi Zhao, Ran Tao, Xiangliang Yang, Zhonghong Gao^!*. Nano titanium dioxide photocatalytic protein tyrosine nitration:A potential hazard of TiO2 on skin. Biochemical and Biophysical Research Communications. 2008, 370(4):675-80. 
9. Naihao Lu, Mingyi Zhang, Hailing Li, ZhonghongGao^!*, Completely different effects of desferrioxamine on hemin/nitrite/H2O2-induced bovine serum albumin nitration and oxidation. Chemical Research in Toxicology. 2008, 21(6), 1229–1234.
10. Yuling Zhao, Hailing Li,Zhonghong Gao^!*, Huibi Xu. Effects of dietary baicalin supplementation on iron overload induced mouse liver oxidative injury. European Journal of Pharmacology. 2005, 509(2-3): 195-200
11. Ka Bian*, Zhonghong Gao*Norman Weisbrodt and Ferid Murad. The nature of Hemin/iron–induced protein tyrosine nitration. Proceedings of the National Academy of Sciences USA. 2003, 100(10):5712-7 (* Equally contributed to this paper)
12. Zhonghong Gao, Kaixun Huang, Huibi Xu. Protective effects of flavonoids in the roots of Scutellaria baicalensis Georgi against hydrogen peroxide-induced oxidative stress in HS-SY5Y cells. Pharmacological Research. 2001, 43:173-178 (cited: 134)
13. Zhonghong Gao, Kaixun Huang, Xiangliang Yang, Huibi Xu. Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochimica et Biophysica Acta, 1999, 1472(3): 643-650.(cited: 316) 

獲獎與榮譽

2004年獲湖北省青年杰出人才基金

2005年入選教育部“新世紀優秀人才支持計劃”