香港大學(xué)孫紅哲教授做客第271期化苑講壇
報(bào)告題目：Integrative-omics approach for metals in medicine
報(bào) 告 人 ：孫紅哲教授
報(bào)告時(shí)間：2017年6月16日（周五）下午15:00
報(bào)告地點(diǎn)：化學(xué)樓二樓一號(hào)會(huì)議室
邀 請(qǐng) 人 ：劉紅梅教授
報(bào)告人簡(jiǎn)介：
孫紅哲教授，1996年獲倫敦大學(xué)博士學(xué)位，現(xiàn)為香港大學(xué)化學(xué)系教授、博導(dǎo)，中山大學(xué)“計(jì)劃”獲得者、國(guó)家杰出青年基金獲得者，先后榮獲香港裘槎基金會(huì)“裘槎杰出研究者獎(jiǎng)”、香港大學(xué)杰出研究者獎(jiǎng)以及香港大學(xué)杰出研究生導(dǎo)師獎(jiǎng)。主要從事化學(xué)與生物、醫(yī)學(xué)的交叉前沿研究，擅長(zhǎng)生物無機(jī)化學(xué)、金屬組學(xué)/金屬蛋白質(zhì)組學(xué)及金屬蛋白質(zhì)的結(jié)構(gòu)生物學(xué)。迄今發(fā)表論文150余篇，總引用達(dá)6000余次，h因子大于43。
報(bào)告內(nèi)容：
Metal ions play crucial roles in life processes either as an essential elements or therapeutical/diagnostic agents. It is crucial to identify metal-protein interactions at a proteome-wide scale which are difficult due to certain weak and transient interactions. We developed an integrated approach consisting of gel electrophoresis and inductively coupled plasma mass spectrometry, immobilized metal affinity chromatography (IMAC), fluorescence and bioinformatics to identify metal-associated proteins using bismuth antiulcer drug as an example. We have identified metal-associated proteins as well as to quantify the metals for fast metallome/proteome-wide profiling of metal-binding proteins. The multi-targets of bismuth(III) provide a rational basis in understanding the high efficacy and low antibiotic resistance of this class of bismuth drugs. We also show that an integrative metallomic approach represents a powerful tool for metals in biology and medicine as well as pharmacology of metallodrugs.
